![]() This is another cause of inter-operator variability of tumor volume measurement. In many cases, the tumor exists close enough to non-tumor FDG uptake, which requires manual interaction to extract just the tumor. Semi-automated separation between tumor and non-tumor. The details of the algorithm and the data about reliability are published in PLOS ONE and were presented at the Annual Meeting of Society of Nuclear Medicine 2014 in St. In this context, we proposed a new semi-automated algorithm to consistently define the liver VOI. However, if the liver VOI is placed manually, this again causes inter-operator variability due to heterogeneity of liver uptake. By doing that, inter-study variability of SUV (or SUL) can be minimized. According to PERCIST criteria ( Wahl et al., J Nucl Med 2009), the tumor boundary on FDG PET-CT is recommended to be determined using the threshold derived from liver (mean + 3 SD, or 1.5 mean + 2 SD). Then, the operator is requested to determine whether each mass is tumor or non-tumor. In Metavol, the computer first search the entire body PET images to mark up the mass higher than a certain threshold. ![]() Creating VOI needs to be carefully done with long time and labor required. In most conventional environments, you need to enclose the tumor first (using spherical or irregular volume of interest (VOI)), followed by the computer pick up volumes higher than a certain threshold. In order to reduce time and inter-operator variability, this application has 3 convenient functions.Īutomated mass detection first. All the functions you need for daily diagnosis of oncology FDG PET-CT are here.Īs a tool for metabolic volume measurement. Panning, zooming, and paging are easy with simple mouse operations. Place a volume-of-interest (spherical, ellipsoidal, cuboid, or sylindrical) to measure SUVmax, SUVpeak, and SUVmean. You can use it as a basic and simple PET-CT viewer: transaxial, coronal, sagittal, and maximum intensity projection (MIP) views for PET, CT, and PET-CT fused images. Metavol can be used either as a simple PET-CT viewer or as an advanced PET-CT image analyzer.Īs a simple viewer. The entire source code (sorry old version only) of Metavol is available at. ![]() Metavol is light software and does not require a high-spec computer. Sorry, Metavol currently does not work on Mac OS or Linux. The latest version is released on October 9, 2018.ĭownload sample DICOM files (DICOM format, a no-disease case)
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